a tool for identifying drug-targetable redox-active disulphides

Granzyme C

Intramolecular

Cysteine 50 and cysteine 66

A redox-regulated disulphide may form within Granzyme C between cysteines 50 and 66.

Details

Redox score ?

80

PDB code

Structure name

structure of grc

Structure deposition date

2009-01-27

Thiol separation (Å)

2

Half-sphere exposure sum ?

91

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

50

Residue number B

66

Peptide name

Granzyme C

Ligandability

Cysteine 50 of Granzyme C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Granzyme C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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